In 1506, Leonardo da Vinci, the most famous artist of his time, is accused of the murder of Caterina da Cremona.

In March 2021, it was announced that Leonardo would return for a second season. The series recounts Leonardo da Vinci's extraordinary life through the works that made him famous and through the stories hidden within those works, revealing little by little the inner torments of a man obsessed with attaining perfection. The series was produced by Italian Lux Vide in collaboration with Rai Fiction, Sony Pictures Entertainment, with Frank Spotnitz's Big Light Productions and Freddie Highmore's Alfresco Pictures in association with France Télévisions and RTVE. Leonardo is a historical drama created by Frank Spotnitz and Steve Thompson. Rai 1 and Rai 4K (Italy), VOX (Germany), The CW (United States)